Outcomes of Various Classes of Oral Antidiabetic Drugs on Nonalcoholic Fatty Liver Disease
Key Points
Question Among sodium-glucose cotransporter 2 (SGLT2) inhibitors, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, and sulfonylureas, which class of oral antidiabetic drugs (OADs) is the preferred therapeutic option for patients with both nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D)?
Findings In this nationwide cohort study involving 80 178 patients diagnosed with T2D and concurrent NAFLD in Korea, spanning 219 941 person-years, SGLT2 inhibitors were associated with a higher likelihood of NAFLD regression and lower incidence of adverse liver-related outcome parameters when compared with other OADs.
Meaning The results from this study suggest that SGLT2 inhibitors may be the preferred choice among OADs for individuals with both NAFLD and T2D, highlighting the need for additional research to determine whether a shift in prescribing practices is warranted.